Innovative Methodology Large-Scale Chronically Implantable Precision Motorized Microdrive Array for Freely Behaving Animals

Large-scale chronically implantable precision motorized microdrive array for freely behaving animals.

Multiple single-unit recording has become one of the most powerful in vivo electro-physiological techniques for studying neural circuits. The demand has been increasing for small and lightweight chronic recording devices that allow fine adjustments to be made over large numbers of electrodes across multiple brain regions. To achieve this, we developed precision motorized microdrive arrays that ...

Miniature motorized microdrive and commutator system for chronic neural recording in small animals.

The use of chronically implanted electrodes for neural recordings in small, freely behaving animals poses several unique technical challenges. Because of the need for an extremely lightweight apparatus, chronic recording technology has been limited to manually operated microdrives, despite the advantage of motorized manipulators for positioning electrodes. Here we describe a motorized, miniatur...

Design and assembly of an ultra-light motorized microdrive for chronic neural recordings in small animals.

The ability to chronically record from populations of neurons in freely behaving animals has proven an invaluable tool for dissecting the function of neural circuits underlying a variety of natural behaviors, including navigation(1) , decision making (2,3), and the generation of complex motor sequences(4,5,6). Advances in precision machining has allowed for the fabrication of light-weight devic...

A wireless neural recording system with a precision motorized microdrive for freely behaving animals

The brain is composed of many different types of neurons. Therefore, analysis of brain activity with single-cell resolution could provide fundamental insights into brain mechanisms. However, the electrical signal of an individual neuron is very small, and precise isolation of single neuronal activity from moving subjects is still challenging. To measure single-unit signals in actively behaving ...

A wireless system with a motorized microdrive for neural recording in freely behaving animals(モーター駆動型マイクロドライブによる神経活動 の無線記録システムの開発) Recordings from single neurons in freely behaving animals provide insights into the brain functions in the natural state. However, isolating activity of single neurons